Discuss one mutation that has a negative effect on the body

Question
Mutations occur when DNA is not replicated properly. Fortunately, for the most part, cells have a mechanism to correct the mutation or destroy it. Sometimes that mechanism fails and the mutation survives. Spend some time researching mutations.

Discuss one mutation that has a negative effect on the body
Find another mutation that can have a positive effect on the body.
For both mutations, explain how they occur: spontaneously or through a mutagenic effect, and
What effects do these mutations have on the individual with this condition?